For research use only.

Applications: WB, IHC      

Species Cross-Reactivity: H,

Molecular Weight: ~70KD        

Isotype: IgG

Storage Buffer & Condition: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Store : -20°C. Do not aliquot the antibody.

Recommended dilutions: WB: 1:1,000 IHC: 1:100

Optimal dilutions should be determined by the end user.

Specificity: The COX1 Rabbit Polyclonal antibody detects endogenous COX1 proteins. 

Background: Cyclooxygenase-1 (COX-1), also known as prostaglandin G/H synthase 1,

prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1, is an enzyme that in humans is

encoded by the PTGS1 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive

COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue

distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and

growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not

result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins

PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described

Applications:WB-Western blot   IHC-Immunochemistry   IF-Immunofluorescence   IP-Immunoprecipitation

                         ChIP-Chormatin Immunoprecipitation

Reactivity:   H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep