For research use only.

Applications: WB, IHC      

Species Cross-Reactivity: H,

Molecular Weight: ~70KD        

Isotype: IgG

Storage Buffer & Condition: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Store : -20°C. Do not aliquot the antibody.

Recommended dilutions: WB: 1:1,000 IHC: 1:100

Optimal dilutions should be determined by the end user.

Specificity: The COX2 Rabbit Polyclonal antibody detects endogenouse COX2 proteins 

Background: Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is

an enzyme that in humans is encoded by the PTGS2 gene. There are two isozymes of COX encoded by distinct

gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of

expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant

cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but

does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1

proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described

Applications:WB-Western blot   IHC-Immunochemistry   IF-Immunofluorescence   IP-Immunoprecipitation   

                          ChIP-Chormatin Immunoprecipitation

Reactivity:   H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep