For research use only.

Application: IHC  

Species Cross-Reactivity: H, R, M   

Molecular Weight: N/A         

Isotype: IgG1

Storage Buffer & Condition: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Store : -20°C. Do not aliquot the antibody.

Recommended dilutions: IHC: 1:200

Optimal dilutions should be determined by the end user.

Specificity: CD10 Mouse Monoclonal Antibody detects endogenous CD10 proteins. 

Background: CD10 is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted

peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural

tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein,

the neprilysin ectodomain is released into the extracellular domain after it has been transported from the

Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component

of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to

amyloid beta.

Applications:WB-Western blot   IHC-Immunochemistry   IF-Immunofluorescence   IP-Immunoprecipitation  

                            ChIP-Chormatin Immunoprecipitation

Reactivity:   H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep