For research use only.

Applications: IHC  

Species Cross-Reactivity: H, M, R   

Molecular Weight: ~37KD    

Isotype: IgG1

Storage Buffer & Condition: PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Store : -20°C. Do not aliquot the antibody.

Recommended dilutions: IHC: 1:200

Optimal dilutions should be determined by the end user.

Specificity: The CD68 antibody detects endogenous CD68 proteins 

Background: The CD68 antigen is a 37kD transmembrane protein that is post-translationally glycosylated

to give a protein of 87-115kD. CD68 is specifically expressed by tissue macrophages, Langerhans cells and

at low levels by dendritic cells. It could play a role in phagocytic activities of tissue macrophages, both in

intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It binds to tissue-

and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid

recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to

crawl over selectin bearing substrates or other cells.

Applications:WB-Western blot   IHC-Immunochemistry   IF-Immunofluorescence   IP-Immunoprecipitation

                          ChIP-Chormatin Immunoprecipitation

Reactivity:   H-Human R-Rat M-Mouse Mk-Monkey Dg-Dog Ch-Chicken Hm-Hamster Rb-Rabbit Sh-Sheep